C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 281/14 (2006.01) A61K 31/175 (2006.01) A61K 31/275 (2006.01) C07C 323/48 (2006.01)
Patent
CA 2223935
A compound of general formula (I) useful as an anticonvulsant for disorders of the central nervous system wherein: R1, R2, R3 and R4 may be the same or different and each represents a hydrogen or halogen atom, or a C1-9alkyl, C3- 9cycloalkyl, cyano, C1-9alkoxy or C6-10aryloxy group; R5 represents a hydrogen atom or a C1-9alkyl, C3-9cycloalkyl or C6-10aryl group; and X is oxygen or sulfur; or a pharmaceutically-acceptable salt thereof. The compound may be administered orally for treating convulsions in humans or animals.
Le composé de formule générale (I) ou un de ses sels pharmaceutiquement acceptables est utile comme anticonvulsivant dans des maladies du système nerveux central. Dans la formule, R?1¿, R?2¿, R?3¿ et R?4¿ peuvent être identiques ou différents et représentent chacun hydrogène, un atome halogène ou un groupe alkyle C¿1-9?, cycloalkyle C¿3-9?, cyano, alcoxy C¿1-9? ou aryloxy C¿6-10?; R?5¿ désigne un atome d'hydrogène ou un groupe alkyle C¿1-9?, cycloalkyle C¿3-9? ou aryle C¿6-10?; et X désigne oxygène ou soufre. On peut administrer ce composé par voie orale pour traiter des convulsions chez des êtres humains ou des animaux.
Dimmock Jonathan Richard
Puthucode Ramanan Narayan
Mbm & Co.
The University Of Saskatchewan
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