Seneca valley virus based compositions and methods for...

C - Chemistry – Metallurgy – 07 – H

Patent

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Details

C07H 21/04 (2006.01) C07H 21/02 (2006.01) C07K 16/00 (2006.01) C12N 15/85 (2006.01) C12N 15/86 (2006.01) C12Q 1/68 (2006.01) C12Q 1/70 (2006.01)

Patent

CA 2540177

The present invention relates to a novel RNA picornavirus that is called Seneca Valley virus ("SVV"). The invention provides isolated SVV nucleic acids and proteins encoded by these nucleic acids. Further, the invention provides antibodies that are raised against the SVV proteins. Because SVV has the ability to selectively kill some types of tumors, the invention provides methods of using SVV and SVV polypeptides to treat cancer. Because SVV specifically targets certain tumors, the invention provides methods of using SVV nucleic acids and proteins to detect cancer. Additionally, due to the information provided by the tumor-specific mechanisms of SVV, the invention provides methods of making new oncolytic virus derivatives and of altering viruses to have tumor-specific tropisms.

La présente invention concerne un nouveau picornavirus à ARN, appelé le virus de "Seneca Valley" (" SVV"). Cette invention a aussi trait à des acides nucléiques isolés du virus de "Seneca Valley" et des protéines codées par ces acides nucléiques. En outre, ladite invention a trait à des anticorps qui sont élaborés contre les protéines du virus de "Seneca Valley". Comme ledit virus présente la capacité de tuer sélectivement certains types de tumeurs, cette invention a pour objet des méthodes d'utilisation du virus de "Seneca Valley" et des polypeptides associés dans le traitement de cancer. Etant donné que le virus de "Seneca Valley" cible spécifiquement certaines tumeurs, l'invention concerne des méthodes d'utilisation d'acides nucléiques et de protéines du virus de "Seneca Valley" dans la détection de cancer. Par ailleurs, au moyen des informations fournies par les mécanismes spécifiques de tumeurs du virus de "Seneca Valley", il est possible d'obtenir des méthodes d'élaboration de nouveaux dérivés oncolytiques du virus et de modification de virus pour qu'ils présentent des tropismes spécifiques de tumeurs.

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