Senescent cell-derived inhibitors of dna synthesis

Details Senescent cell-derived inhibitors of dna synthesis Senescent cell-derived inhibitors of dna synthesis

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 9/127 (2006.01) A61K 31/70 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) C07K 14/47 (2006.01) C12N 15/62 (2006.01) C12N 15/88 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2235810

The use of liposomal formulations, particularly formulations of positively charged and neutral lipids facilitates cellular uptake of SDI molecules. The transcription and/or expression of SDI-1-encoding nucleic acid molecules is facilitated by constructs that contain intervening untranslated regions.

L'utilisation de formulations liposomiques, en particulier, des formulations de lipides neutres et positivement chargés facilite le captage cellulaire de molécules d'inhibiteurs produits dans des cellules sénescentes (SDI). La transcription et/ou l'expression de molécules d'acide nucléique codant SDI-1 est facilitée par des produits de recombinaison contenant des régions intervenantes non traduites.

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