Senile amyloid precursor protein and an antibody specific...

C - Chemistry – Metallurgy – 12 – N

Patent

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167/139, 167/45,

C12N 15/12 (2006.01) C07K 14/00 (2006.01) C07K 14/47 (2006.01) C07K 14/81 (2006.01) C07K 16/18 (2006.01) C07K 16/38 (2006.01) C12N 1/20 (2006.01) C12N 5/10 (2006.01) C12P 21/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/577 (2006.01) G01N 33/68 (2006.01)

Patent

CA 1340802

A protein comprising a specific amino acid sequence including at least 55 amino acids and having a protease inhibiting activity is disclosed. Further, an antibody specific for the protein, a DNA coding for the protein, a complementary DNA to the DNA and RNA's corresponding to these DNA's, and human chromosomal DNA fragment coding for the protein are also disclosed. The protein, antibody, DNA RNA and human chromosomal DNA fragment of the present invention are useful for diagnosis of dysbolism in the central nervous system, including senile dementia Alzheimer's type.

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