Sense mrna therapy

Details Sense mrna therapy Sense mrna therapy

C - Chemistry, Metallurgy

12

N

C12N 15/67 (2006.01) C07H 21/04 (2006.01) C12P 21/00 (2006.01)

Patent

CA 2304982

The present invention describes novel methods for the stabilization of mRNA. These alterations increase stability of mRNA and enable its use in sense RNA therapy to transiantly express proteins in a cell. Accordingly, the present invention is directed to methods for making such modifications, compositions comprising such modifications, and the use of such compositions in treating disease states.

L'invention concerne de nouveaux procédés servant à stabiliser l'ARNm. Ces modifications augmentent la stabilité de l'ARNm, et permettent de l'utiliser dans une thérapie génique à base d'ARN sens afin d'exprimer de façon transitoire des protéines dans une cellule. Elle concerne, de ce fait, des procédés servant à réaliser ces modifications, des compositions contenant ces modifications et la mise en application de ces compositions pour le traitement de maladies.

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