Sensitive and rapid methods of using chimeric receptors to...

Details Sensitive and rapid methods of using chimeric receptors to... Sensitive and rapid methods of using chimeric receptors to...

C - Chemistry, Metallurgy

12

Q

C12Q 1/66 (2006.01) C12Q 1/68 (2006.01) G01N 33/564 (2006.01) C07K 14/72 (2006.01) G01N 33/74 (2006.01)

Patent

CA 2701198

The present invention provides methods and compositions useful in the diagnosis and management of autoimmune diseases. In particular, the present invention provides improved methods and compositions for the diagnosis and management of Graves' disease. The methods of the present invention not only avoids the need for radioactivity and are much simpler, economical, and rapid than methods traditionally used for the diagnosis of Graves' disease, but also improve upon the sensitivity and detection abilities of previous luciferase-based autoantibody detection assays. Such improvements are based upon the superior performance of assays comprising a chimeric TSH receptor in the presence of a glucocorticoid including, but not limited to, dexamethasone.

La présente invention concerne des procédés et des compostions utiles dans le diagnostic et la gestion de maladies auto-immunes. En particulier, la présente invention concerne des procédés et des compositions améliorés pour le diagnostic et la gestion de la maladie de Graves. Les procédés selon la présente invention éliminent non seulement le recours à la radioactivité et sont beaucoup plus simples, économiques, et rapides que les procédés utilisés traditionnellement pour le diagnostic de la maladie de Graves, mais améliorent également les capacités de sensibilité et de détection des dosages pour la détection d'anticorps précédents basée sur la luciférase. De telles améliorations sont basées sur l'efficacité supérieure de dosages comportant un récepteur chimérique TSH en présence d'un glucocorticoïde comprenant, entre autres, le dexaméthasone.

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