Sensitization to another anticancer therapy and/or...

A - Human Necessities – 61 – K

Patent

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A61K 38/04 (2006.01) A61K 31/00 (2006.01) A61K 31/282 (2006.01) A61K 31/337 (2006.01) A61K 31/475 (2006.01)

Patent

CA 2566850

The use of a GST-activated anticancer compound in the manufacture of a medicament for sensitizing a mammal, especially a human, to another anticancer therapy (that is, an anticancer therapy that is not treatment with a GST- activated anticancer compound - including chemotherapy, molecular targeted therapy, biologic therapy, and radiotherapy, each used as monotherapy or two or more used in combination), or for ameliorating a side effect of another anticancer therapy in a mammal, especially a human. Compositions containing a GST-activated anticancer compound for these uses. A method of sensitizing a mammal, especially a human, to another anticancer therapy, by administering a sensitizing effective amount of a GST activated anticancer compound. A method of ameliorating a side effect of another anticancer therapy in a mammal, especially a human, by administering an ameliorating effective amount of a GST activated anticancer compound. The GST activated anticancer compound is preferably a compound of US Patent No. 5,556,942, and more preferably canfosfamide, especially as the hydrochloride salt.

L~utilisation d~un composé anticancéreux activé par GST dans la fabrication d~un médicament pour sensibiliser un mammifère, et en particulier un humain, à une autre thérapie anticancéreuse (à savoir, une thérapie anticancéreuse qui n~est pas un traitement impliquant un composé anticancéreux activé par GST - y compris la chimiothérapie, la thérapie par ciblage moléculaire, la thérapie biologique, et la radiothérapie, chacune d~entre elles étant utilisée en monothérapie ou en combinaison avec d~autres thérapies), ou pour améliorer un effet secondaire d~une autre thérapie anticancéreuse chez un mammifère, et en particulier chez un humain. Préparations contenant un composé activé par GST à ces fins. Une méthode pour sensibiliser un mammifère, en particulier un humain, à une autre thérapie anticancéreuse en lui administrant un dose effective sensibilisante de composé anticancéreux activé par GST. Une méthode pour améliorer un effet secondaire d~une autre thérapie anticancéreuse chez un mammifère, et en particulier chez un humain, en lui administrant une dose effective amélioratrice de composé anticancéreux activé par GST. Le composé anticancéreux activé par GST est de préférence un composé du Brevet américain No. 5,556,942, le canfosfamide étant encre mieux, en particulier en chlorhydrate de sel.

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