Separation method and device with chromatographic zones with...

B - Operations – Transporting – 01 – D

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B01D 15/18 (2006.01) B01D 15/02 (2006.01) B01D 15/08 (2006.01)

Patent

CA 2348719

The invention concerns a method for separating at least a constituent of a mixture in a set of looping chromatographic columns, the loop comprising at least a point for injecting a load, a point for drawing off the raffinate, a point for injecting an eluting agent and a point for drawing of the extract. The method consists in: determining between an injection point and a drawing off point or vice-versa a chromatographic zone and at the end of a specific time interval, the whole set of injection points and drawing off points are offset by the same number of columns or column sections and advantageously from one column or one column section in a specific direction defined with respect to that of the flow of the main fluid circulating through the loop. During said time interval, the offsetting of the different injection and drawing off points of at least one column or column section is carried out at different times such that the length of the zones defined by the different points varies. The invention is useful in particular for separating stereoisomers for pharmaceutical purposes.

On décrit un procédé de séparation d'au moins un composant d'un mélange dans un ensemble de colonnes chromatographiques en boucle, la boucle comportant au moins un point d'une injection de charge, un point d'un soutirage de raffinat, un point d'une injection d'un éluant et un point d'un soutirage d'extrait, dans lequel on détermine entre un point d'injection et un point de soutirage ou vice-versa une zone chromatographique et au bout d'une période de temps donné, l'ensemble des points d'injection et de soutirage se trouvent décalés du même nombre de colonnes ou tronçons de colonne et avantageusement d'une colonne ou tronçon de colonne dans une direction donnée définie par rapport à celle de l'écoulement d'un fluide principal circulant à travers la boucle. Au cours de la période, on effectue le décalage des différents points d'injection et de soutirage d'au moins une colonne ou tronçon de colonne à des temps différents de manière à ce que la longueur des zones définies par lesdits différents points soit variable. Application à la séparation notamment des stéréoisomères pour la pharmacie.

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