Separation of glyco-containing entities

Details Separation of glyco-containing entities Separation of glyco-containing entities

B - Operations, Transporting

01

D

B01D 15/08 (2006.01) B01J 20/32 (2006.01)

Patent

CA 2408117

A method for the separation of at least one glyco-containing entity, in which method said entity or entities dissolved/suspended in a liquid is/are contacted with a polymer, which has boronic acid covalently coupled to said polymer and previously has been equilibrated with said liquid, to form a boronate-glyco-complex whereafter the glyco-containing entity or entities is/are released from the boronate-modified polymer is disclosed, wherein said liquid contains one or more substances capable of forming complexes with boronic acids/boronate anions, which complexes are weaker than the boronate- glyco-complex but stronger than complexes formed by interactions others than glyco-boronate.

L'invention concerne un procédé de séparation d'au moins une entité contenant du glyco, selon lequel l'entité ou les entités dissoute(s)/en suspension dans un liquide est/sont mis en contact avec un polymère qui a de l'acide boronique couplé de façon covalente à ce polymère et a été préalablement équilibré avec ce liquide, pour former un complexe glyco-boronate. Ensuite, l'entité ou les entités contenant du glyco est /sont libérée(s) du polymère modifié par du boronate. Ce liquide contient au moins une substance capable de former des complexes avec des acides boroniques/anions de boronate, lesquels complexes sont plus faibles que le complexe glyco-boronate plus forts que les complexes formés par des interactions autres que le glyco-boronate.

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