Seprase as a marker for cancer

Details Seprase as a marker for cancer Seprase as a marker for cancer

G - Physics

01

N

G01N 33/574 (2006.01)

Patent

CA 2706115

The present invention relates to a method aiding in the assessment of cancer. It discloses the use of the human fibroblast activation protein (FAP/seprase) as a universal marker of different cancer types. Seprase aids in the assessment of pulmonary or lung cancer (LC) or of colon cancer, e.g. of non-small cell lung carcinoma (NSCLC) or colorectal cancer (CRC), but also likely of other specific types of cancer. Such specific cancer types are e.g. esophagus, head and neck cancer, stomach cancer, bile duct cancer, pancreas cancer, kidney cancer, cervix cancer, ovary cancer, breast cancer, bladder cancer, endometrium cancer or prostate cancer. Furthermore, it especially relates to a method for assessing cancer from a liquid sample, derived from an individual by measuring seprase in said sample. Measurement of seprase can, e.g., be used in the early detection of cancer or in the surveillance of patients who undergo surgery.

La présente invention concerne un procédé d'aide à l'évaluation du cancer. On utilise la protéine d'activation des fibroplastes humains (FAP/séprase) comme marqueur universel de différents types de cancer. La séprase aide à l'évaluation du cancer pulmonaire ou des poumons (LC) ou du cancer du colon, par exemple le carcinome du poumon non à petites cellules (NSCLC) ou le cancer colorectal (CRC), mais est également susceptible d'évaluer d'autres types spécifiques de cancer. De tels types spécifiques de cancer sont par exemple le cancer de l'oesophage, le cancer de la tête et du cou, le cancer de l'estomac, le cancer de la voie biliaire principale, le cancer du pancréas, le cancer du rein, le cancer du col de l'utérus, le cancer de l'ovaire, le cancer du sein, le cancer de la vessie, le cancer de l'endomètre ou le cancer de la prostate. De plus, l'invention concerne particulièrement un procédé d'évaluation du cancer à partir d'un échantillon liquide, dérivé d'un individu en mesurant la séprase dans ledit échantillon. La mesure de la séprase peut, par exemple, être utilisée dans la détection précoce du cancer ou dans la surveillance de patients qui subissent une chirurgie.

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