Sequence of nucleotides and peptides gse 24.2 of dyskerin,...

Details Sequence of nucleotides and peptides gse 24.2 of dyskerin,... Sequence of nucleotides and peptides gse 24.2 of dyskerin,...

C - Chemistry, Metallurgy

12

N

C12N 9/12 (2006.01) A61K 38/17 (2006.01) A61P 43/00 (2006.01)

Patent

CA 2625981

The invention relates to a compound which induces or activates telomerase activity, based on the nucleotide sequence of the GSE 24.2 fragment of dyskerin or the protein or peptide sequence encoded by said nucleotide sequence. The invention also relates to vectors containing said sequence and cells transformed with same and pharmaceutical compositions containing all of the aforementioned elements. Said compositions can be used in the treatment of diseases from the following group: ageing or acceleration of ageing, neurodegenerative diseases and congenital dyskeratosis.

La présente invention concerne un composé inducteur ou activateur de l'activité télomérase fondé sur la séquence de nucléotides du fragment GSE 24.2 de la dyskérine ou la séquence protéique ou peptidique codée par ladite séquence de nucléotides. L'invention concerne également des vecteurs comprenant ladite séquence et des cellules transformées à l'aide de ladite séquence, ainsi que des compositions pharmaceutiques qui contiennent tous ces éléments. Ces compositions peuvent être utilisées dans le traitement de maladies du groupe suivant: le vieillissement ou l'accélération du vieillissement, les maladies neurodégénératives et la dyskératose congénitale.

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