Sequence-specific binding oligomers for nucleic acids and...

C - Chemistry – Metallurgy – 07 – H

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C07H 21/00 (2006.01) C07F 9/6558 (2006.01) C07F 9/6561 (2006.01) C07H 19/04 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2196306

The invention relates to oligomers consisting completely or partially of 1,5- anhydrohexitol nucleoside analogues represented by general formula (I), wherein B is a heterocyclic ring which is derived from a pyrimidine or purine base, such as cytosine, 5-methylcytosine, uracil and thymine, or deaza derivatives thereof, or adenine, guanine, 2,6-diaminopurine, hypoxanthine and xanthine, or deaza derivatives thereof.

L'invention concerne des oligomères constitués en partie ou en totalité de nucléosides du type 1,5-anhydrohexitol représentés par la formule générale (I). Dans cette formule, B est un groupe hétérocyclique dérivé d'une base pyrimidique ou purique, comme par exemple la cytosine, la 5-méthylcytosine, l'uracile et la thymine, ou leurs dérivés désaza, ou encore comme par exemple l'adénine, la guanine, la 2,6-diaminopurine, l'hypoxanthine et la xanthine ou leurs dérivés désaza.

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