Sequence specific dna binding by p53

Details Sequence specific dna binding by p53 Sequence specific dna binding by p53

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) A61K 31/70 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) C07H 21/04 (2006.01) C07K 14/47 (2006.01) G01N 33/50 (2006.01) G01N 33/574 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2070979

Specific sequences in the human genome are the sites of strong binding of wild-type p53 protein, but not mutant forms of the protein. These sequences are used diagnostically to detect cells in which the amount of wild-type p53 is diminished. The sequences can also be used to screen for agents which correct for loss of wild-type p53 to DNA in cancer cells.

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