C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/85 (2006.01) A01K 67/027 (2006.01) A61K 31/70 (2006.01) A61K 48/00 (2006.01) C07K 14/47 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2250099
DNA sequences including a fragment of the sequence ahead of the coding portion of the SM22 protein gene, or a sequence hybridisable therewith under highly stringent conditions, said fragment being capable of inducing specific gene expression in eukaryotic cells, as well as a sequence coding for a protein or RNA of therapeutical interest, are disclosed. Said sequence or a vector containing same may be used for treating coronary diseases, particularly restenosis.
Séquences d'ADN comprenant: un fragment de la séquence en amont de la partie codante du gène de la protéine SM22, ou d'une séquence hybridant dans des conditions de forte stringence à ladite séquence en amont, ledit fragment étant susceptible d'induire une expression spécifique d'un gène dans des cellules eucaryotes; et une séquence codant pour une protéine, ou un ARN, d'intérêt thérapeutique. Cette séquence, ou un vecteur la contenant, peut être utilisée pour le traitement des maladies coronariennes, en particulier de la resténose.
Li Zhenlin
Mericskay Mathias
Mossler Herber
Paulin Denise
Small Victor
Institut Pasteur
Robic
Universite Paris 7
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