Sequences characteristic of bladder cancer

C - Chemistry – Metallurgy – 12 – Q

Patent

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Details

C12Q 1/68 (2006.01) A61K 31/70 (2006.01) A61K 38/00 (2006.01) A61K 39/395 (2006.01) C07H 21/02 (2006.01) C07H 21/04 (2006.01) C07K 16/00 (2006.01) C12N 15/63 (2006.01) C12P 21/08 (2006.01)

Patent

CA 2385893

There is provided a method of diagnosing the presence of bladder cancer in a patient by analyzing a tissue sample from the patient for the presence of at least one expressed gene wherein the presence of the expressed gene is indicative of bladder cancer. Also provided by the present invention is a polynucleotide sequence whose expression is indicative of bladder cancer. A marker for bladder cancer is also provided. There are also provided methods of diagnosing bladder cancer by screening for the presence of at least one expressed gene wherein the presence of the expressed gene is indicative of bladder cancer. Methods of treating and regulating bladder cancer-associated pathologies by administering to a patient a therapeutically effective amount of a ribozyme, antisense olignucleotide, or agonist against the nucleic acids sequences of the present invention are alos provided.

L'invention porte: sur un procédé de diagnostic du cancer de la vessie chez un patient par analyse d'un prélèvement de tissu pour y rechercher au moins un gène exprimé dont la présence est révélatrice du cancer de la vessie; sur une séquence de polynucléotide dont la présence est révélatrice du cancer de la vessie; sur un marqueur de cancer de la vessie; sur des procédés de diagnostic du cancer de la vessie par criblage pour détecter la présence d'au moins un gène exprimé dont la présence est révélatrice du cancer de la vessie; et sur des procédés de traitement et régulation des pathologies associées au cancer de la vessie par administration à un patient de doses à efficacité thérapeutique d'un ribozyme, d'un oligonucléotide antisens, ou d'un agoniste, agissant contre les séquences d'acides nucléiques de la présente invention.

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