C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/53 (2006.01) C07H 21/02 (2006.01) C07H 21/04 (2006.01) C07K 16/40 (2006.01) C12N 5/00 (2006.01) C12N 5/10 (2006.01) C12N 9/02 (2006.01) C12N 15/00 (2006.01) C12P 21/06 (2006.01) C12P 21/08 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2388612
The present disclosure provides the nucleotide sequence encoding a cell surface NADH oxidase/protein disulfide-thiol interchange protein (tNOX) characteristic of neoplastic and virus-infected cells. Also provided are recombinant DNA molecules comprising a sequence portion encoding full length or truncated tNOX, recombinant host cell which express ful length or truncated tNOX, methods for recombinant production of tNOX or truncated tNOX, and diagnostic methods which employ either nucleotide sequences of the neoplastic cell-specific tNOX or antibodies specific for the rNOX protein.
La présente invention concerne une séquence nucléotidique codant une protéine NADH d'échanges disulfide-thiol oxydase/protéine de surface cellulaire (tNOX) qui caractérise les cellules néoplasiques et infectées par des virus. Elle concerne aussi des molécules d'ADN recombinantes comprenant une partie de séquence codant une tNOX pleine longueur ou tronquée, une cellule hôte recombinante exprimant une tNOX pleine longueur ou tronquée et des procédés diagnostiques qui utilisent des séquences nucléotidiques de la tNOX spécifique aux cellules néoplasiques ou des anticorps spécifiques de la protéine rNOX.
Chueh Pin-Ju
Morre D. James
Morre Dorothy M.
Mckay-Carey & Company
Purdue Research Foundation
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