C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 31/70 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12N 15/11 (2006.01) C12N 15/85 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01)
Patent
CA 2308565
The present invention relates to methods for the diagnosis, evaluation and treatment of metastatic diseases using metastatic sequences, such as caveolin, to target metastatic cells. According to the methods of the present invention, certain cancers, including metastatic prostate cancer, may be treated by therapies which suppress expression of the caveolin gene. The present invention relates to biological technologies designed to block the activity of caveolin or the function of caveolae, including vector delivery of antisense caveolin sequences, the use of anti-caveolin antibodies, the use of promoters, and other approaches targeting the expression of caveolin.
La présente invention à trait à des procédés permettant de diagnostiquer, d'évaluer ou de traiter les maladies métastatiques en utilisant des séquences métastatiques, telles que des séquences de cavéoline, pour cibler des cellules métastatiques. Selon les procédés de cette invention, certains cancers, notamment le cancer métastatique de la prostate, peuvent être traités par des thérapies qui suppriment l'expression du gène de la cavéoline. Par ailleurs, cette invention concerne des technologies biologiques conçues pour bloquer l'activité de la cavéoline ou la fonction de la cavéole, notamment la distribution par vecteurs des séquences de cavéoline anti-sens, l'utilisation d'anticorps anti-cavéoline, l'utilisation de promoteurs, ainsi que d'autres approches ciblant l'expression de la cavéole.
Baylor College Of Medicine
Mbm & Co.
LandOfFree
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