C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/63 (2006.01) A01K 67/027 (2006.01) A61K 31/7088 (2006.01) A61K 48/00 (2006.01) C07K 14/47 (2006.01) C12N 15/85 (2006.01)
Patent
CA 2431193
The invention relates to novel promoter sequences derived from a portion upstream of the coding sequence of the gene for the CARP protein (Cardiac Ankyrin Repeat Protein), and which are capable of controlling the level and the specificity of expression of a transgene in vivo in cardiac muscle cells. The invention thus describes novel compositions, constructs, vectors and their uses in vivo for the transfer and expression of a nucleic acid in vivo in cardiac muscle cells. The subject of the present invention is also the use of the promoter sequences for generating transgenic animals which constitute models for studying certain cardiac pathologies.
L'invention concerne de nouvelles séquences de promoteurs dérivées d'une partie en amont de la séquence de codage du gène pour la protéine CARP (protéine de répétition de l'ankyrine cardiaque), et pouvant réguler le niveau et la spécificité d'expression d'un transgène in vivo dans les cellules des muscles cardiaques. L'invention concerne ainsi de nouvelles compositions, des produits de recombinaison, des vecteurs et leurs utilisations in vivo dans le transfert et l'expression d'un acide nucléique in vivo dans les cellules des muscles cardiaques. La présente invention concerne également l'utilisation des séquences de promoteurs pour générer des animaux transgéniques constituant des modèles dans l'étude de certaines pathologies cardiaques.
Benoit Patrick
Branellec Didier
Chen Ju
Chien Kenneth
Schwartz Bertrand
Centelion
Gencell S.a.
Robic
The Regents Of The University Of California
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