Sequencing of oligonucleotides by mass spectrometry

Details Sequencing of oligonucleotides by mass spectrometry Sequencing of oligonucleotides by mass spectrometry

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) C07H 21/00 (2006.01) C12N 15/10 (2006.01) G01N 27/00 (2006.01)

Patent

CA 2609823

A method of sequencing nucleic acids is provided which uses ion ratios derived by measuring ion abundance at both a high and low collision energy. These ion rations are useful for assigning charge states to product ions, as well as for sequencing the terminal sequences. In addition, methods for using internal ions to sequence the nucleic acids are described.

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