Sequencing of peptides by mass spectrometry

Details Sequencing of peptides by mass spectrometry Sequencing of peptides by mass spectrometry

G - Physics

01

N

G01N 33/543 (2006.01) G01N 33/53 (2006.01) G01N 33/58 (2006.01) G01N 33/68 (2006.01) H01J 49/00 (2006.01) H01J 49/04 (2006.01)

Patent

CA 2302877

A strategy for semiautomatic sequencing of argentinated (silver-containing) oligopeptides is described. The method of sequencing described is based on a search algorithm that identifies a triplet peak relationship in a product ion spectrum of the [M + Ag]+ ion of an oligopeptide. The ions that constitute a triplet are [b~ + OH + Ag] + , [b~- H + Ag]+ , and [a~ - H + Ag]+ , which are separated by 18 and 28 ~/~ units, respectively. The difference in the ~/~ values of adjacent triplets identifies the residue that is "cleaved". Observation of the [y~ + H + Ag]+ ion containing the cleaved residue confirms the assignment.

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