Sequential delivery of immunogenic molecules via adenovirus...

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A61K 39/00 (2006.01) A61K 48/00 (2006.01) C12N 7/01 (2006.01) C12N 15/86 (2006.01) C12N 15/861 (2006.01)

Patent

CA 2563538

An immunogenic regimen is provided. The regimen involves sequential administration of a recombinant adenoviral vector and a recombinant adeno- associated viral vector, each of which delivers a heterologous expression cassette encoding the same immunogenic product, or a cross-reactive immunogenic product. Also provided are products containing the vectors for use in the regimen of the invention.

L'invention concerne un régime immunogène, qui consiste à administrer séquentiellement un vecteur adénoviral recombinant et un vecteur viral adéno-associé recombinant, libérant chacun une cassette d'expression hétérologue codant pour le produit immunogène, ou un produit immunogène à réaction croisée. L'invention porte également sur des produits contenant des vecteurs à utiliser dans le régime de l'invention.

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