Sequential drug delivery systems

A - Human Necessities – 61 – K

Patent

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Details

A61K 47/46 (2006.01) A61K 9/00 (2006.01) A61K 9/02 (2006.01) A61K 9/20 (2006.01) A61K 45/00 (2006.01) A61K 47/00 (2006.01)

Patent

CA 2451106

The invention relates to methods and composition for improving absorption and dissolution of active ingredients of drugs. The invention provides a method of administration of an active ingredient to a mammal through a transmucosal route that includes delivering the active ingredient to a desired site in a body of the mammal, and, sequentially, at the desired site, promoting dissolution and absorption of the active ingredient. In a preferred embodiment, the ph of the localized environment of the active ingredient is sequentially modified to promote dissolution and absorption.

L'invention se rapporte à des méthodes et des compositions conçues pour améliorer l'absorption et la dissolution de principes actifs de médicaments. La présente invention concerne une méthode d'administration d'un principe actif à un mammifère par voie transmuqueuse, comprenant les étapes consistant : à libérer le principe actif au niveau d'un site souhaité dans le corps du mammifère, puis à séquentiellement favoriser la dissolution et l'absorption de ce prinicpe actif au niveau dudit site. Dans un mode de réalisation préféré de la présente invention, le pH de l'environnement local du principe actif est séquentiellement modifié afin de stimuler la dissolution et l'absorption dudit principe actif.

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