Serine amino acid derived prodrugs of propofol,...

C - Chemistry – Metallurgy – 07 – C

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C07C 229/22 (2006.01) A61K 31/198 (2006.01) A61P 23/00 (2006.01) A61P 25/00 (2006.01) C07C 227/42 (2006.01)

Patent

CA 2586410

The present invention provides a prodrug of propofol and crystalline forms thereof, methods of making the propofol prodrug and crystalline forms thereof, pharmaceutical compositions of the propofol prodrug and crystalline forms thereof, methods of using the propofol prodrug and crystalline forms thereof and pharmaceutical compositions thereof to treat diseases or disorders such as headache pain, post chemotherapy or post operative surgery nausea and vomiting, neurodegenerative disorders, and mood disorders.

La présente invention décrit une prodrogue du propofol et des formes cristallines de ladite prodrogue, des méthodes de synthèse de la prodrogue de propofol et de ses formes cristallines, des préparations pharmaceutiques de la prodrogue de propofol et de ses formes cristallines, des méthodes d'emploi de la prodrogue de propofol, de ses formes cristallines et de ses préparations pharmaceutiques dans le traitement de maladies ou de troubles tels que les maux de tête, les nausées et vomissements post-chimiothérapie ou post-opération de chirurgie, les troubles neurodégénératifs et les troubles de l'humeur.

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