Serine derivative

Details Serine derivative Serine derivative

C - Chemistry, Metallurgy

07

D

C07D 409/06 (2006.01) A61K 31/395 (2006.01) A61K 31/695 (2006.01) C07D 307/52 (2006.01) C07D 307/54 (2006.01) C07D 333/20 (2006.01) C07D 333/24 (2006.01) C07D 405/06 (2006.01) C07D 409/14 (2006.01) C07D 413/06 (2006.01) C07D 417/06 (2006.01) C07F 7/10 (2006.01)

Patent

CA 2160459

A serine derivative represented by the general formula (I) Image (I) (symbols in the formula represent the following meanings; X: a sulfur atom or an oxygen atom, Y: a nitrogen atom or CH, R1 and R2: the same or different from each other and each represents a hydrogen atom, a lower alkyl group or a protecting group for the amino group, or R1 and R2 may be combined together to form a four- to nine-membered nitrogen- containing cycloalkyl group, R3: a hydrogen atom, a carboxyl group, a protected carboxyl group, an aralkyl group, or a lower alkyl group unsubstituted or substituted with a hydroxyl group, R4: a hydrogen atom or a hydroxyl group, R5: a hydrogen atom or a lower alkyl group, A: a lower alkylene group, B: 1) a saturated or unsaturated four- to ten-membered nitrogen-containing cycloalkyl group unsubstituted or substituted with a lower alkyl group or an aralkyl group or 2) a bicyclic nitrogen-containing hydrocarbon ring radical resulting from the condensation of a four- to eight-membered nitrogen-containing cycloalkyl group with a benzene ring, and ???: a single or double bond) or a pharmaceutically acceptable salt thereof, which has an anti-PCP (phencyclidine) action and is useful as a psychotropic drug.

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