Serine protease inhibitor

Details Serine protease inhibitor Serine protease inhibitor

C - Chemistry, Metallurgy

12

N

C12N 15/15 (2006.01) A23J 1/04 (2006.01) A23L 1/305 (2006.01) A61K 38/55 (2006.01) A61K 38/57 (2006.01) A61P 7/02 (2006.01) C07H 21/04 (2006.01) C07K 14/435 (2006.01) C07K 14/81 (2006.01) C12N 1/19 (2006.01) C12N 1/21 (2006.01) C12N 15/66 (2006.01) C12N 15/70 (2006.01) C12N 15/74 (2006.01) C12N 15/79 (2006.01) C12N 15/81 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2356424

The invention provides a protein which exhibits, inter alia, anti-thrombin activity and divalent metal cation binding activity. The protein can be readily extracted from the green-lipped mussell, Perna canaliculus, and formulated into foodstuffs, nutraceuticals and the like, and has a molecular weight of about 55 kDa and an amino acid sequence which includes one or more of the following: (a) DGEQCNDGQN (SEQ ID NO.1), (b) QGGHEVESERVACCVIGRA (SEQ ID NO. 2), (c) GQSHPEIVH (SEQ ID NO. 3), (d) YHGHDDA (SEQ ID NO. 4), (e) VVNEVHH (SEQ ID NO. 5)

L'invention concerne une protéine présentant, entre autres, une activité antithrombotique et une activité de fixation de cations métalliques divalents. Cette protéine peut être obtenue facilement à partir de moules de Nouvelle Zélande, Perna canaliculus, et formulée dans des produits alimentaires, des aliments fonctionnels et analogues; et elle possède un poids moléculaire d'environ 55 kDa, ainsi qu'une séquence d'acides aminés comportant une ou plusieurs parmi les suivantes: (a) DGEQCNDGQN (SEQ ID NO.1), (b) QGGHEVESERVACCVIGRA (SEQ ID NO. 2), (c) GQSHPEIVH (SEQ ID NO. 3), (d) YHGHDDA (SEQ ID NO. 4), (e) VVNEVHH (SEQ ID NO. 5)

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