Serine protease inhibitors

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) A61K 31/70 (2006.01) A61K 38/57 (2006.01) A61K 48/00 (2006.01) C07H 21/04 (2006.01) C07K 14/81 (2006.01) C07K 16/38 (2006.01) C12N 15/11 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2315976

A serine protease inhibitor, characterized by having a domain with four cysteines, and a sequence of 0 to 20 amino acids is present between the first and second cysteines, or the serine protease inhibitor has a domain with six cysteines, and a sequence of 7 to 20 amino acids is present between the first and second cysteines.

L'invention concerne un inhibiteur de sérine-protéinase qui se caractérise en ce qu'il présente un domaine comportant quatre cystéines. Une séquence de 13 aminoacides se situe entre une première cystéine et une deuxième cystéine. Une séquence de 18 aminoacides se situe entre la deuxième cystéine et la troisième cystéine. Une séquence de 2 aminoacides se situe entre la troisième cystéine et la quatrième cystéine. Les inhibiteurs de sérine-protéinase s'utilisent dans le traitement de maladies inflammatoires, telles que par ex. des inflammations du col aiguës ou chroniques ou des tonsillites, ainsi que dans la prophylaxie de l'emphysème pulmonaire.

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