Serine protease inhibitors for treatment of bacterial...

A - Human Necessities – 61 – K

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A61K 38/57 (2006.01) A61K 45/00 (2006.01) A61P 31/04 (2006.01)

Patent

CA 2536918

A novel method of treating and preventing bacterial diseases is provided. In particular, the present invention relates to compositions and methods for inhibition of Gram negative, Gram positive and acid fast bacilli in general and tuberculosis (TB), mycobacterium avium complex (MAC), and anthrax in particular. Thus, the invention relates to modulation of cellular activities, including macrophage activity, and the like. More particularly, the present invention relates to the inhibitory compounds comprising naturally occurring and man-made inhibitors of serine protease.

L'invention porte sur une nouvelle méthode de traitement et de prévention de maladies bactériennes et en particulier sur des compositions et procédés d'inhibition des bacilles Gram négatifs, Gram positifs et acidorésistants et notamment ceux de la tuberculose, et du complexe mycobacterium avium et du charbon. L'invention porte également sur la modulation de l'activité cellulaire dont celle des macrophages et analogues et plus particulièrement sur des composés inhibiteurs comprenant des inhibiteurs naturels ou de synthèse de la protéase sérine.

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