C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
C12P 21/08 (2006.01) A61K 39/395 (2006.01) C07K 16/40 (2006.01) C12N 5/12 (2006.01) C12N 5/18 (2006.01) C12N 15/02 (2006.01) C12Q 1/37 (2006.01) G01N 33/573 (2006.01) G01N 33/577 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2332131
The present invention is directed to a monoclonal antibody binding selectively to neurosin obtained from hybridomas, in particular strain 2B2-6 and strain S2E5, showing stable proliferation ability. These hybridomas are obtained by fusing mouse spleen cells having a high antibody titer against neurosin with mouse-derived myeloma cells, screening fused cells being highly reactive with neurosin, and thus producing an antibody that binds specifically to neurosin. By using this antibody, various diseases in which neurosin participates can be diagnosed.
L'invention concerne un anticorps monoclonal se liant spécifiquement à la neurosine obtenue à partir d'hybridomes, notamment les souches 2B2-6 et S2E5 qui manifestent une capacité stable de prolifération. On obtient ces hybridomes en faisant ce qui suit: on fusionne les cellules de la rate de souris, qui possèdent un titre d'anticorps plus élevé contre la neurosine, avec les cellules myélomateuses d'origine murine; on crible les cellules fusionnées à forte capacité de réaction avec la neurosine et; on produit par ce procédé un anticorps se liant spécifiquement à la neurosine. En utilisant cet anticorps on peut diagnostiquer diverses maladies auxquelles participe la neurosine.
Kominami Katsuya
Mitsui Shinichi
Okui Akira
Yamaguchi Nozomi
Fuso Pharmaceutical Industries Ltd.
Kirby Eades Gale Baker
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