C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/57 (2006.01) A61K 8/02 (2006.01) A61K 8/66 (2006.01) A61Q 19/00 (2006.01) A61Q 19/10 (2006.01) C11D 3/386 (2006.01) C12N 9/50 (2006.01) C12N 9/54 (2006.01)
Patent
CA 2325568
The present invention relates to variants of serine proteases having decreased immunogenicity relative to their corresponding wild-type proteases. More particularly, the present invention relates to variants having a modified amino acid sequence of a wild-type amino acid sequence, wherein the modified amino acid sequence comprises a substitution of one or more specifically identified positions corresponding to subtilisin BPN'. The invention further relates to mutant genes encoding such variants and cleaning and personal care compositions comprising such variants.
Cette invention se rapporte à des variants de sérine-protéases ayant une immunogénicité inférieure à celle des protéases de type sauvage correspondantes. Cette invention se rapporte plus particulièrement à des variants ayant une séquence d'acides aminés modifiée par rapport à une séquence d'acides aminés de type sauvage, la séquence d'acides aminés modifiée comprenant une substitution d'une ou de plusieurs positions spécifiquement identifiées correspondant à la subtilisine BPN'. Cette invention se rapporte en outre à des gènes mutants codant ces variants et à des compositions de produits de nettoyage et de soins personnels contenant ces variants.
Correa Paul Elliott
Rubingh Donn Nelton
Sikorski Elizabeth Ellen
Gowling Lafleur Henderson Llp
The Procter & Gamble Company
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