Serine protease variants having peptide ligase activity

Details Serine protease variants having peptide ligase activity Serine protease variants having peptide ligase activity

C - Chemistry, Metallurgy

12

N

C12N 15/57 (2006.01) C07K 2/00 (2006.01) C07K 14/61 (2006.01) C12N 9/22 (2006.01) C12N 9/54 (2006.01) C12P 21/00 (2006.01) C12P 21/02 (2006.01)

Patent

CA 2087342

The invention relates to serine protease variants derived from precursor serine proteases via recombinant and/or chemical methods to form protease variants having improved peptide ligase activity. The invention also includes novel ligation substrates which in combination with the serine protease variants and a second ligation substrate are capable of forming a ligation product. The invention also relates to methods for forming such ligation products and the products formed thereby.

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