Serine-threonine protein kinase and parp modulators

Details Serine-threonine protein kinase and parp modulators Serine-threonine protein kinase and parp modulators

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/4353 (2006.01) A61K 31/5383 (2006.01) C07D 495/04 (2006.01) C07D 513/04 (2006.01) G01N 33/573 (2006.01) C07D 498/06 (2006.01)

Patent

CA 2661842

The invention relates in part to molecules having certain biological activities that include, but are not limited to, inhibiting cell proliferation, modulating protein kinase activity and modulating polymerase activity. Molecules of the invention can modulate casein kinase (CK) activity and/or poly(ADP-ribose)polymerase (PARP) activity. The invention also relates in part to methods for using such molecules.

La présente invention concerne en partie des molécules présentant certaines activités biologiques qui comprennent, entre autres et sans limitation, l'inhibition de la prolifération cellulaire, la modulation de l'activité de la protéine kinase et la modulation de l'activité de la polymérase. Les molécules selon l'invention peuvent moduler l'activité de la caséine kinase (CK) et/ou l'activité de la poly(ADP-ribose)polymérase (PARP). Cette invention porte également en partie sur des procédés d'utilisation de ces molécules.

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