A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/443 (2006.01) A61K 31/4965 (2006.01) A61K 31/5415 (2006.01) C07D 209/08 (2006.01) C07D 241/02 (2006.01) C07D 279/02 (2006.01) C07D 295/088 (2006.01) C07D 295/13 (2006.01) C07D 401/12 (2006.01) C07D 513/04 (2006.01)
Patent
CA 2332505
Compounds with 5HT7 receptor affinity (some of which are novel) useful for lowering IOP, improving blood flow to the optic nerve head and the retina, providing neuroprotection, and treating retinal diseases are disclosed. The Compounds are also useful for treating sleep disorders, depression, and other psychiatric disorders, such as, schizophrenia, anxiety, obsessive compulsive disorder, circadian rhythm disorders, and centrally and peripherally mediated hypertension. Compositions and methods for their use are also disclosed.
L'invention concerne des composés possédant une affinité à l'égard du récepteur de 5HT¿7? (dont certains sont nouveaux), utiles pour abaisser la tension intra-oculaire, pour améliorer l'écoulement sanguin vers la tête du nerf optique et la rétine, pour apporter une protection neurologique et traiter des maladies de la rétine. Ces composés sont également utiles pour traiter les troubles du sommeil, la dépression ainsi que d'autres troubles psychiatriques tels que la schizophrénie, l'anxiété, les troubles obsessifs impulsifs, les troubles du rythme circadien, ainsi que l'hypertension d'origine centrale ou périphérique. L'invention concerne encore des compositions et des procédés destinés à l'emploi de ces composés.
Chen Hwang-Hsing
Dean Thomas R.
May Jesse A.
Sharif Najam A.
Alcon Laboratories Inc.
Goudreau Gage Dubuc
LandOfFree
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