Serotonergic agents

Details Serotonergic agents Serotonergic agents

C - Chemistry, Metallurgy

07

D

C07D 405/14 (2006.01) A61K 31/44 (2006.01) A61P 25/28 (2006.01) C07D 213/00 (2006.01) C07D 319/00 (2006.01) C07D 405/12 (2006.01)

Patent

CA 2428039

Novel piperazine derivatives are provided having the formula (III) wherein R1 is cyano, nitro, trifluoromethyl or halogen or pharmaceutically acceptable acid addition salts thereof, which are useful as 5-HT 1A receptor antagonists.

L'invention concerne des dérivés de pipérazine représentés par la formule (III), dans laquelle R¿1? est cyano, nitro, trifluorométhyle ou halogène, ou bien des sels d'addition d'acide correspondants qui sont pharmaceutiquement acceptables, les dérivés en question ou bien les sels correspondants étant utiles comme antagonistes de récepteur 5-HT¿1A?.

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