Sertraline oral concentrate

Details Sertraline oral concentrate Sertraline oral concentrate

A - Human Necessities

61

K

A61K 31/135 (2006.01) A61K 9/00 (2006.01) A61K 47/10 (2006.01)

Patent

CA 2346335

The present invention provides an essentially nonaqueous, liquid pharmaceutical concentrate composition for oral administration containing sertraline or a pharmaceutically acceptable salt thereof and one or more pharmaceutically acceptable excipients. The present invention also provides a use of this concentrate composition to prepare an aqueous solution of sertraline. In addition, the present invention provides a method of using this concentrate composition to treat or prevent a variety of diseases or conditions. Finally, the present invention provides the compound, (1S-cis)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N- methyl-1-naphthalenamine methanesulfonate.

L'invention concerne une composition concentrée pharmaceutique liquide, essentiellement non aqueuse, conçue pour être administrée par voie orale, contenant de la sertraline, ou un sel de celle-ci pharmaceutiquement acceptable, et au moins un excipient pharmaceutiquement acceptable. L'invention porte également sur une utilisation de cette composition concentrée pour la préparation d'une solution aqueuse de sertraline. L'invention concerne en outre un procédé d'utilisation de ladite composition pour traiter ou prévenir divers maladies ou états. Enfin, l'invention traite du composé, (1S-cis)-4-(3,4-dichlorophényl)-1,2,3,4-tétrahydro-N-méthyl-1-naphtalène amine méthanesulfonate.

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