Sertraline salts and sustained-release dosage forms of...

C - Chemistry – Metallurgy – 07 – C

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Details

C07C 211/42 (2006.01) A61K 9/20 (2006.01) A61K 9/22 (2006.01) A61K 9/52 (2006.01) A61K 31/135 (2006.01) A61P 25/00 (2006.01) A61P 37/00 (2006.01) A61K 9/00 (2006.01) A61K 9/16 (2006.01) A61K 9/28 (2006.01) A61K 9/50 (2006.01)

Patent

CA 2290966

Sustained release dosage forms of sertraline which release sertraline at a rate between 1 mgA/hr and 40 mgA/hr. The dosage forms may exhibit an initial delay period during which sertraline is released at a rate less than 1 mgA/hr. The present invention is further directed to an acetate salt, an L-lactate salt and an L-aspartate salt of sertraline, pharmaceutical compositions thereof and methods of using that salt for treating various conditions and disorders. The present invention is also directed to processes for preparing sertraline acetate, sertraline L-lactate and sertraline L-aspartate.

Formes posologiques de sertraline, à libération prolongée, qui libèrent la sertraline à une vitesse de 1 mgA/h et 40 mgA/h. Lesdites formes peut se caractériser par un retard initial pendant lequel la sertraline est libéré à une vitesse de moins de 1 mgA/h. L'invention concerne, de plus, un sel acétate, un sel L-lactate et un sel L-aspartate de sertraline, des compositions pharmaceutiques les contenant et des procédés d'utilisation dudit sel pour le traitement d'affections et de troubles divers. Elle se rapporte également à des procédés de préparation d'acétate de sertraline, de L-lactate de sertraline et de L-aspartate de sertraline.

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