Serum amyloid a protein in inflammation and obesity

Details Serum amyloid a protein in inflammation and obesity Serum amyloid a protein in inflammation and obesity

G - Physics

01

N

G01N 33/53 (2006.01)

Patent

CA 2589277

The present invention relates to the discovery that acute-phase serum amyloid protein A (A-SAA) is a biomarker for obesity and certain abnormal conditions. The present invention, therefore, provides methods of diagnosing obesity or an abnormal condition in a subject The present invention also provides methods of monitoring the progression of obesity or an abnormal condition in a subject. The present invention also relates to treating obesity or an abnormal condition comprising reducing the levels of active SAA1 and/or SAA2 in a subject in need thereof.

L'invention concerne la découverte que la protéine sérum amyloïde A de phase aiguë (A-SAA) est un biomarqueur pour l'obésité et certains états anormaux. Par conséquent, l'invention concerne des méthodes permettant de diagnostiquer l'obésité ou un état anormal chez un sujet. L'invention concerne également des méthodes permettant de surveiller le progrès de l'obésité ou d'un état anormal chez un sujet. Enfin, l'invention concerne un traitement de l'obésité ou d'un état anormal qui consiste à réduire les taux de SAA1 active et/ou de SAA2 active chez un sujet nécessitant un tel traitement.

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