Serum biomarkers for the early detection of lung cancer

Details Serum biomarkers for the early detection of lung cancer Serum biomarkers for the early detection of lung cancer

G - Physics

01

N

G01N 33/574 (2006.01) G01N 33/68 (2006.01) G01N 33/543 (2006.01)

Patent

CA 2681667

Methods and kits are provided for determining the probability of lung cancer, for managing treatment of subjects with potential lung cancer and for molecular staging of lung tumors. The methods include determining an amount of each member of a panel of biomarkers in a sample from the subject, wherein the panel of biomarkers comprises at least two of the proteins al-pha-1-antitrypsin, carcinoembryonic antigen, squamous cell carcinoma antigen, retinol binding protein, transferrin, and haptoglobin; and assigning the subject to a group having a higher or lower probability of lung cancer based on the determined amount of each biomarker the panel.

L'invention concerne des procédés et des kits pour déterminer la probabilité de souffrir d'un cancer du poumon, pour gérer le traitement de sujets souffrant potentiellement d'un cancer du poumon et pour l'évaluation moléculaire des tumeurs pulmonaires. Les procédés comprennent la détermination d'une quantité de chaque élément d'un groupe de biomarqueurs dans un échantillon du sujet, le groupe de biomarqueurs comprenant au moins deux des protéines alpha-1 -antitrypsine, un antigène carcino-embryonaire, un antigène du carcinome malpighien, la protéine de liaison au rétinol, la transferrine et l'haptoglobine; et l'affectation du sujet à un groupe ayant une probabilité supérieure ou inférieure de cancer du poumon sur la base de la quantité déterminée de chaque biomarqueur du groupe.

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