C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
167/114
C07K 16/24 (2006.01) C07K 14/52 (2006.01) A61K 38/00 (2006.01)
Patent
CA 1168981
84 ABSTRACT OF THE DISCLOSURE The invention relates to SERUM-DERIVED "LEUKORE- CRUITIN", which is A PROTEIN MEDIATOR OF INFLAMMATION FROM MAMMALIAN SERUM specifically inducing positive leukocytosis reaction and leukocyte recruitment from the bone marrow into the blood of animals and humans without biological side-reactions. The process for the production and isolation of leukorecruitin is characterized in that mammalian serum is subjected to regulated and limited proteolysis by contact activation, the protein is then separated from other foreign constituents and proteins of serum in the form of a crude serum protein concentrate fraction, and/or the protein is separated from other serum-proteins by chromatography on hydroxy- apatite. Leukorecruitin has very valuable pharma- cological effects and can be used in compositions for specifically influencing the defense state of the animal or human body and for diagnostic pur- poses in hematogolical disorders.
385708
Kirby Eades Gale Baker
Max Planck Gesellschaft Zur Forderung Der Wissenschaften E.v.
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