Serum immunoregulatory polypeptide and uses therefor

Details Serum immunoregulatory polypeptide and uses therefor Serum immunoregulatory polypeptide and uses therefor

C - Chemistry, Metallurgy

07

K

167/37, 530/15.0

C07K 14/47 (2006.01) A61K 38/17 (2006.01) C07K 16/18 (2006.01) G01N 33/53 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1339868

Previously unisolated serum immunoregulatory polypeptides (SIPs) having a molecular weight of approximately 14,000 to 31,000 are provided. The SIPs may be obtained from hemorrhagic serum of mammals and have been shown to activate suppressor T-cells and suppress lymphocyte proliferation and interleukin production. There is a significant homology between SIPs of different mammalian species. The SIPs have far reaching implications in allograft and transplant situations where suppression of the immune response and/or induction of tolerance are desirable, as well as in the treatment of auto-immune diseases.

610746

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