Serum immunoregulatory polypeptides and uses therefor

Details Serum immunoregulatory polypeptides and uses therefor Serum immunoregulatory polypeptides and uses therefor

C - Chemistry, Metallurgy

07

K

C07K 14/47 (2006.01) A61K 38/10 (2006.01) A61K 38/17 (2006.01) C07K 7/08 (2006.01) C07K 16/18 (2006.01) G01N 33/577 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2222863

Previously unisolated serum immunoregulatory polypeptides (SIPs) having a molecular weight of approximately 14,000 to 31,000 are provided. The SIPs may be obtained from hemorrhagic serum of mammals and have been shown to activate suppressor T-cells and suppress lymphocyte proliferation and interleukin production. There is a significant homology between SIPs of different mammalian species. The amino acid sequence of an SIP having a molecular weight of about 16,000 is provided. In addition, immunosuppressive polypeptides are identified which have the formula: X-Met-Asp-Ala-His-Pro-Pro-Arg-Leu-Phe-Ala- Cys-Ser-Y, wherein X is an amino acid sequence having from 0 to 10 amino acids and Y is an amino acid sequence having from 0 to 110 amino acids.

Cette invention se rapporte à des polypeptides immunorégulateurs du sérum (PIS), non encore isolés jusqu'ici, ayant un poids moléculaire d'environ 14 000 à 31 000. Ces PIS peuvent être obtenus à partir de sérum hémorragique de mammifères et on a découvert qu'ils activent les lymphocytes T suppresseurs et qu'ils suppriment la prolifération des lymphocytes et la production d'interleukine. Il y a une importante homologie entre les PIS de différentes espèces de mammifères. La séquence d'acides aminés d'un PIS ayant un poids moléculaire d'environ 16 000 est décrite. On a en outre identifié des polypeptides immunosuppresseurs ayant la formule: X-Met-Asp-Ala-His-Pro-Pro-Arg-Leu-Phe-Ala-Cys-Ser-Y, où X est une séquence d'acides aminés comprenant 0 à 10 acides aminés et Y est une séquence d'acides aminés comprenant 0 à 110 acides aminés.

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