C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/55 (2006.01) A61K 31/70 (2006.01) A61K 38/46 (2006.01) C07K 16/40 (2006.01) C12N 9/16 (2006.01) C12N 9/18 (2006.01) C12Q 1/68 (2006.01) G01N 33/573 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01)
Patent
CA 2194390
Human serum paraoxonase enzyme and DNA (RNA) encoding such serum paraoxonase enzymes are disclosed. Also provided is the procedure for producing such polypeptides by recombinant techniques. Uses of such polypeptides include their use as an antidote for organophosphate poisoning and to prevent neuronal cell death. Diagnostic assays for identifying mutations in a nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention are also disclosed.
Paraoxonase sérique humaine, ADN (ARN) codant de telles enzymes et procédé de production de tels polypeptides par techniques de recombinaison. Ces polypeptides peuvent s'utiliser comme antidotes contre l'empoisonnement par organophosphates et pour prévenir la mort des cellules neuronales. Des dosages diagnostiques destinés à identifier des mutations dans une séquence d'acide nucléique codant un polypeptide de la présente invention et à détecter des niveaux modifiés de ce polypeptide sont également décrits.
He Wei Wu
Hudson Peter L.
Ruben Steven M.
Gowling Lafleur Henderson Llp
Human Genome Sciences Inc.
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