Serum protein profiling for the diagnosis of epithelial cancers

Details Serum protein profiling for the diagnosis of epithelial cancers Serum protein profiling for the diagnosis of epithelial cancers

G - Physics

01

N

G01N 33/48 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2525746

The present invention provides biomolecules and the use of these biomolecules for the differential diagnosis of epithelial cancers or an acute and chronic inflammation of the epithelium. In particular the present invention provides methods for detecting biomolecules within a test sample as well as a database comprising of mass profiles of biomolecules specific for healthy subjects, subjects having a precancerous lesion, subjects having an epithelial cancer or a metastasised epithelial cancer or subjects having an acute and chronic inflammation of the epithelium. Furthermore, the present invention provides methods for the characterization of said biomolecules using gas phase ion spectrometry. In addition, the present invention provides methods for the identification of said biomolecules provided that they are proteins or polypeptides. The invention further provides kits for the differential diagnosis of epithelial cancers or an acute and chronic inflammation of the epithelium.

L'invention concerne des biomolécules et leur utilisation afin d'effectuer un diagnostic différentiel des cancers épithéliaux et/ou de l'inflammation aiguë et chronique de l'épithélium. D'une manière plus spécifique, l'invention concerne des méthodes permettant de détecter des biomolécules dans un échantillon d'essai ainsi que dans une base de données comprenant des profils de masse de biomolécules spécifiques de sujets sains, de sujets souffrant d'une lésion précancéreuse, de sujets souffrant d'un cancer épithélial ou d'un cancer épithélial métastasé ou de sujets souffrant d'une inflammation aiguë et chronique de l'épithélium. L'invention concerne également des méthodes permettant de caractériser lesdites biomolécules au moyen de la spectrométrie d'ions en phase gazeuse. L'invention concerne en outre des méthodes permettant d'identifier lesdites biomolécules à la condition qu'elles soient des protéines ou des polypeptides. L'invention concerne enfin des trousses permettant d'effectuer un diagnostic différentiel des cancers épithéliaux et/ou de l'inflammation aiguë et chronique de l'épithélium.

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