C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
530/7.06
C07K 7/06 (2006.01) A61K 38/00 (2006.01)
Patent
CA 1259449
ABSTRACT OF THE DISCLOSURE The invention relates to novel peptide analogs of the serum thymic factor that structurally modified, in comparison with the natural substance, both in their N- terminal and C-terminal parts and inside the amino-acid sequence. These new thymic facts analogs are of general formula I A - Gly - Gly - Ser - Asn - B - C - NH - R (I) in which A is pGlu, Gln, Ala-Lys-Ser-Gln, pGlu-Ala-Lys-Ser-Gln or Gln-Ala-Lys-Ser-Gln, B and C are Gly, Phe, Leu, Ala or a direct bond and R is H, and alkyl with 1 to 6 carbon atoms or a 2-phenylethyl. Depending on their chemical structure, these new thymic factor analogs, possess either agonistic (immunostimulative) or antagonistic (immunosuppressory) properties. A process for preparing these new thymic factor analogs is also disclosed.
497699
Cerny Martin
Kasafirek Evzen
Kocis Petr
Krepelka Jiri
Rovensky Jozef
Robic Robic & Associes/associates
Spofa Spojene Podniky Pro Zdravotnickou Vyrobu
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