Set of antiangiogenic molecules and use thereof

Details Set of antiangiogenic molecules and use thereof Set of antiangiogenic molecules and use thereof

A - Human Necessities

61

K

A61K 39/395 (2006.01) A61K 31/7088 (2006.01) C07K 14/515 (2006.01)

Patent

CA 2723822

The invention relates to an antiangiogenic pharmaceutical composition containing at least one molecule selected from the group comprising a molecule of antisense nucleic acid of VEGF 165, a molecule of antisense nucleic acid of the alpha-9 domain that forms integrin alpha-9/beta-1 and a molecule of VAP-1-specific antibody, a molecule of VEGF 165-specific antibody, a molecule of antibody specific for the alpha-9 domain that forms integrin alpha-9/beta-1 and a molecule of VAP-1--specific antibody and/or combinations thereof and a pharmaceutically acceptable vehicle. The invention also protects the use of said molecules for the production of a drug.

La presente invención se refiere a una composición farmacéutica antiangiogénica que comprende al menos una molécula seleccionada del grupo formado por una molécula de ácido nucleico antisentido de VEGF 165, una molécula de ácido nucleico antisentido del dominio alfa 9 que conforma la integrina alfa 9 beta 1 y una molécula de ácido nucleico antisentido de VAP-1, una molécula de anticuerpo especifica para VEGF 165, una molécula de anticuerpo especifica para el dominio alfa 9 que conforma la integrina alfa 9 beta 1 y una molécula de anticuerpo especifica para VAP-1 y/o combinaciones de las mismas y un vehículo farmacéuticamente aceptable. La presente invención también protege el uso de las mismas para la fabricación de una medicamento.

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