Sex-associated membrane proteins and methods for increasing...

A - Human Necessities – 61 – D

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A61D 19/00 (2006.01) A61D 19/02 (2006.01) A61K 38/17 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 16/18 (2006.01) C07K 16/28 (2006.01) C12N 5/06 (2006.01) C12N 5/08 (2006.01) G01N 33/566 (2006.01) G01N 33/68 (2006.01)

Patent

CA 1341328

A method of sorting living cells based on DNA content. Mammalian sperm subpopulations enriched in X- or Y-sperm. X- and Y-enriched sperm-plasma- membrane vesicles. Substantially pure sex-associated membrane (SAM) proteins. Antibodies'binding to X- or Y-SAM proteins, essentially free of antibodies binding to Y- or X-SAM proteins respectively, or to the H-Y antigen. Semen samples enriched for X- or Y-sperm. Methods for increasing the probability that offspring will be male or female comprising the step of allowing a sperm from an enriched semen sample to fertilize an ovum. Methods for increasing the probability that offspring will be male or female comprising the step of immunizing a female with X- or Y-SAM proteins. Methods of decreasing fertility comprising the step of immunizing a female with both X- and Y-sperm. Methods of increas- ing the probability that mammalian offspring will carry a gene for a particular sex-chromosome linked trait.

602086

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