Sgk and nedd used as diagnostic and therapeutic targets

Details Sgk and nedd used as diagnostic and therapeutic targets Sgk and nedd used as diagnostic and therapeutic targets

C - Chemistry, Metallurgy

07

K

C07K 16/40 (2006.01) A61K 31/7088 (2006.01) A61K 38/00 (2006.01) A61K 38/19 (2006.01) A61K 38/22 (2006.01) A61K 45/00 (2006.01) A61K 48/00 (2006.01) C12N 15/85 (2006.01) C12Q 1/48 (2006.01) C12Q 1/54 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2487730

The invention relates to the use of a substance for the diagnostic detection of Sgk, especially Sgk1 and/or Sgk3, and/or PKB and/or Nedd, especially Nedd4- 2, and to the use of active ingredients which influence glucose transport for treating diseases associated with disturbed glucose transport, and for fattening animals. The invention also relates to a diagnosis kit and a pharmaceutical composition comprising an active quantity of at least one active ingredient which influences glucose transport. The invention further relates to a method for producing transgenic animals.

La présente invention concerne l'utilisation d'une substance pour la détection diagnostique de Sgk (serum and glucocorticoid depedent kinase / kinase régulée par sérum et glucocorticoïde), notamment de Sgk1 et/ou Sgk3, et/ou de PKB (protéine kinase B) et/ou de Nedd (neural precursor cell expressed developmentally downregulated gene / gène sous-régulé par développement exprimé par les cellules précurseurs neuronales), notamment Nedd4-2, ainsi que l'utilisation de principes actifs pour agir sur le transport du glucose afin de traiter des états pathologiques qui sont liés à des troubles du transport du glucose, et pour l'engraissement. L'invention a également pour objet un kit de diagnostic et une composition pharmaceutique comprenant une quantité active d'au moins un principe actif qui agit sur le transport du glucose. De plus, l'invention concerne un procédé pour produire des animaux transgéniques.

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