Sgk2 and sgk3 used as diagnostic and therapeutic targets

Details Sgk2 and sgk3 used as diagnostic and therapeutic targets Sgk2 and sgk3 used as diagnostic and therapeutic targets

A - Human Necessities

61

K

A61K 48/00 (2006.01) A61K 31/00 (2006.01) A61K 31/4741 (2006.01) A61K 31/5517 (2006.01) A61K 31/553 (2006.01) A61K 31/7088 (2006.01) A61P 9/00 (2006.01) A61P 25/00 (2006.01) A61P 37/00 (2006.01) C12Q 1/00 (2006.01) C12Q 1/68 (2006.01) G01N 33/573 (2006.01) C12N 9/12 (2006.01)

Patent

CA 2419472

The invention relates to the use of a substance, which detects sgk2 and/or sgk3, for diagnosing diseases connected with a disturbance of ion channel activity, in particular, sodium and/or potassium channels. The invention also relates to the use of an active ingredient for treating the aforementioned diseases, said active ingredient influencing the expression and/or the function of sgk2 and/or sgk3 and regulating the elimination of Na+ and/or K+ as a result. The preferred active ingredients are staurosporine and/or chelerythrine.

L'invention concerne l'utilisation d'une substance pour la mise en évidence de sgk2 ou de sgk3 afin de diagnostiquer des affections en relation avec une activité perturbée de canaux ioniques, notamment des canaux sodiques ou potassiques. L'invention concerne également l'utilisation d'un principe actif pour le traitement des affections ci-dessus. Selon l'invention, le principe actif influence l'expression ou la fonction de sgk2 ou de sgk3, régulant ainsi l'élimination de Na?+¿ ou l'élimination de K?+¿. Des principes actifs préférés sont la staurosporine ou la chélérythrine.

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