Sh2-containing inositol-phosphatase

Details Sh2-containing inositol-phosphatase Sh2-containing inositol-phosphatase

C - Chemistry, Metallurgy

12

N

C12N 15/55 (2006.01) C07H 21/00 (2006.01) C07K 16/40 (2006.01) C12N 9/16 (2006.01) C12Q 1/42 (2006.01)

Patent

CA 2186573

Novel SH2-containing inositol-phosphatase which has a src homology 2 (SH2) domain and exhibits phosphoIns-5-ptase activity, and nucleic acid molecules encoding the novel protein are disclosed. The invention also relates to methods for identifying substances which affect the binding of the protein to Shc and/or its phosphoIns-5-ptase activity and methods for screening for agonists or antagonists of the binding of the protein and Shc.

Divulgation d'une nouvelle inositol-phosphatase contenant un domaine SH2 qui a un domaine d'homologie src (SH2) et exhibe une activité de phosphoIns-5-ptase, et de molécules d'acide nucléique codant cette nouvelle protéine. La présente invention a aussi pour objet les méthodes pour identifier des substances qui affectent la liaison de la protéine au Shc et/ou son activité de phosphoIns-5-ptase et des méthodes pour cribler des agonistes ou des antagonistes pour la liaison de la protéine à Shc.

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