Shc proteins as therapeutic targets in proliferative diseases

Details Shc proteins as therapeutic targets in proliferative diseases Shc proteins as therapeutic targets in proliferative diseases

C - Chemistry, Metallurgy

07

H

C07H 21/04 (2006.01)

Patent

CA 2548551

This invention provides methods for treating a subject afflicted with a proliferative disorder comprising administering to the subject a therapeutically effective amount of an agent which inhibits the expression of p46 Shc and/or p52 Shc, inhibits the activity of p46 Shc and/or p52 Shc in the subject, or increases the level of phosphorylated p66 Shc in the subject. This invention also provides methods for determining whether an agent inhibits the phosphorylation of p46 Shc or p52 Shc; inhibits dephosphorylation of p66 Shc comprising; or an agent inhibits the binding of a Shc A protein with a protein to which the Shc A protein must bind in a cell in order to carry out its proliferative function. This invention also provides articles of manufacture for use in treating a proliferative disorder in a subject.

Cette invention porte sur des méthodes de traitement d'un sujet souffrant d'une maladie proliférative, cette méthode consistant à administrer au sujet une quantité efficace d'un point de vue thérapeutique d'un agent qui inhibe l'expression de p46 Shc et/ou p52 Shc, ainsi que l'activité de p46 Shc et/ou p52 Shc chez le sujet, ou augmente le taux de p66 Shc phosphorylée chez le sujet. Cette invention porte également sur des méthodes visant à déterminer si un agent inhibe la phosphorylation de p46 Shc ou p52 Shc; inhibe la déphosphorylation de p66 Shc ou si un agent inhibe la liaison d'une protéine Shc A avec une protéine à laquelle la protéine Shc A doit se lier dans une cellule afin d'exercer da fonction proliférative. Cette invention porte, en outre, sur des articles de fabrication destinés à être utilisés dans le traitement d'une maladie proliférative affectant un sujet.

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