Shell-and-core dosage form approaching zero-order drug release

Details Shell-and-core dosage form approaching zero-order drug release Shell-and-core dosage form approaching zero-order drug release

A - Human Necessities

61

K

A61K 9/20 (2006.01) A61K 9/28 (2006.01)

Patent

CA 2396782

Drugs are formulated as oral dosage forms for controlled release in which the release rate limiting portion is a shell surrounding the drug-containing core. The shell releases drug from the core by permitting diffusion of the drug from the core. The shell also promotes gastric retention of the dosage form by swelling upon imbibition of gastric fluid to a size that is retained in the stomach during the postprandial or fed mode.

Selon l'invention, des médicaments sont préparés en tant que formes posologiques orales destinées à une libération commandée dans laquelle la portion de limitation du taux de libération est une enveloppe placée autour du noyau renfermant les médicaments. L'enveloppe libère le médicament à partir du noyau en permettant sa diffusion à partir du noyau. L'enveloppe favorise également la rétention gastrique de la forme posologique en gonflant lors de l'imbibition de fluide gastrique jusqu'à atteindre une certaine dimension qui est retenue dans l'estomac pendant le mode postprandial ou pendant le repas.

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